Functional Mitral Regurgitation (FMR)
Functional mitral valve regurgitation occurs when the mitral valve annulus dilates preventing the mitral valve leaflets from closing together properly causing the backward flow of blood into the left atrium. This decreases the amount of oxygenated blood that is pumped to the
body and can increase symptoms associated with heart failure. Severe FMR is associated with poor long term survival. Regurgitant (backward) blood flow can cause Congestive heart failure, pulmonary edema, atrial fibrillation and in some cases sudden death. Heart
failure is a condition in which the heart is unable to pump enough blood to the body. The heart tries to compensate by growing larger and
this increase in size causes the mitral valve to stretch, which in turn leads to the mitral valve leaking and mitral regurgitation. Unfortunately, this further compromises the function of the heart and so the heart failure worsens over time.
What are the symptoms associated with FMR and heart failure:
• Shortness of breath on exertion
• Chest pain
• Heart palpitations
• Swelling of the feet and ankles
If you have heart failure, you know how this condition affects your quality of life. Simple daily activities like preparing meals, visiting with friends, or even moving from room to room can require major effort and leave you exhausted. An estimated 26 million people suffer from
heart failure worldwide, and the number is growing rapidly.
Prevalence of Valvular Regurgitation
Heart Repair Technologies is a leader in the development of innovative products for cardiovascular medicine. The company’s initial technology platform, the Mitral Bridge™, is designed to address functional mitral regurgitation (FMR) in an open surgical setting and is now transitioning to percutaneous catheter delivered therapy based on positive results shown in a previous clinical trial(1)
The Mitral Bridge™ device has demonstrated the following over multi-year follow up:
• Reduction in MR grade from severe (3+/4+) MR to none/trace or mild (0/1+) in
100% of patients
Low filling gradients at rest (2.3mmHg) & exercise (4.6mmHg) at 2-year follow up.
No outflow tract obstruction (LVOT) throughout follow up.
Preservation of the natural shape and dynamic motion of the mitral annulus has the potential to promote reverse remodeling of a dilated left ventricle in patients with congestive heart failure (CHF) and FMR.
Heart Repair Technologies leadership team is composed of seasoned industry veterans with over 150 years of experience dedicated to the development and success of the next evolution of percutaneous, beating-heart, off pump delivery of the Mitral Bridge™️ for valvular regurgitation.
1.Cerny, S. et al Persistent reduction of mitral regurgitation by implantation of a transannular mitral bridge: durability and
effectiveness of the repair at 2 years—results of a prospective trial.
European Journal of Cardio-Thoracic Surgery 55 (2019) 867–873